On the Probability of Neanderthal Ancestry

On the probability of Neanderthal ancestry.

White Paper 23 - 05 Neanderthal Ancestry Estimator

The genomic landscape of Neanderthal ancestry in present-day humans

Genomic studies have shown thatNeanderthals interbredwithmodern humans,andthatnon-Africanstodayare theproductsof thismixture. The antiquity ofNeanderthal gene flow intomodernhumansmeans thatgenomic regions thatderive fromNeanderthals inanyonehuman todayareusually less thanahundredkilobases in size.However,Neanderthal haplotypes are also distinctive enough that several studies have been able to ...

Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans

Although Neanderthals are extinct, fragments of their genomes persist in contemporary humans. Here we show that while the genome-wide frequency of Neanderthal-like sites is approximately constant across all contemporary out-of-Africa populations, genes involved in lipid catabolism contain more than threefold excess of such sites in contemporary humans of European descent. Evolutionally, these g...

Variation and Functional Impact of Neanderthal Ancestry in Western Asia

Neanderthals contributed genetic material to modern humans via multiple admixture events. Initial admixture events presumably occurred in Western Asia shortly after humans migrated out of Africa. Despite being a focal point of admixture, earlier studies indicate lower Neanderthal introgression rates in some Western Asian populations as compared with other Eurasian populations. To better underst...